Well, yesterday I switched OS to W10 RTM and the default Intel driver had APM enabled. My HD501IJ which was part of a raid 0 started clicking and after a while it got so bad that the entire system froze and I had to shut down the system with the power button. The drive no longer shows up in the BIOS, it's dead.
My HD103SJ also started clicking. Listening to music from it would cause the drive to click. After noticing the load/unload counter go up I googled it and found this thread. Downgrading to the 12.9 driver solved the problem and probably saved one of my drives.
Mobo & affected drives
MSI P67A C45 B3
Affected drives: HD501IJ, HD103SJ